Circadian rhythm - Wikipedia, the free encyclopedia: "sleepiness increases and decreases with a period of approximately 24 hours.[5] In 1918, J.S. Szymanski showed that animals are capable of maintaining 24-hour activity patterns in the absence of external cues such as light and changes in temperature.[6] Ron Konopka and Seymour Benzer isolated the first clock mutant in Drosophila in the early 1970s and mapped the "period" gene, the first discovered genetic component of a circadian clock.[7] Joseph Takahashi discovered the first mammalian 'clock gene' (CLOCK) using mice in 1994.[8][9]
The term "circadian" was coined by Franz Halberg in the late 1950s.[10]
[edit]Criteria
To be called circadian, a biological rhythm must meet these four general criteria:"
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