Circadian rhythm - Wikipedia, the free encyclopedia: "bipolar disorder and some sleep disorders, are associated with irregular or pathological functioning of circadian rhythms. Recent research suggests that circadian rhythm disturbances found in bipolar disorder are positively influenced by lithium's effect on clock genes.[57]
Disruption to rhythms in the longer term is believed to have significant adverse health consequences on peripheral organs outside the brain, particularly in the development or exacerbation of cardiovascular disease.[58] The suppression of melatonin production associated with the disruption of the circadian rhythm may increase the risk of developing cancer.[59] LED lighting suppresses melatonin production five times more than a high pressure sodium light.[60] Depression symptoms from long term nighttime light exposure can be undone by returning to a normal cycle.[61]"
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